Celiac disease is an autoimmune reaction to gluten that remains underdiagnosed. At Vibrant America, we offer a comprehensive panel to help you optimize your treatment outcomes by early detection.
About the disease
Celiac disease is a disorder characterized by intestinal malabsorption of nutrients due to sensitivity to the alcohol-soluble portion of gluten known as gliadin. Wheat, rye, barley, and to a lesser extent, oats contain this protein substance and can induce mucosal damage in the gut causing nonspecific villous atrophy of the small intestine mucosa. Most patients are asymptomatic. This disease has variable clinical manifestations that can lead to severe symptoms such as profound malabsorption, steatorrhea, and wasting. There are associations between celiac disease and Type I diabetes mellitus, thyroid disease and other autoimmune diseases.
Celiac Disease in Adults
- Depression or anxiety
- Seizures or migraines
- Bone loss or osteoporosis
- Irregular menstrual periods
- Infertility or recurrent miscarriage
- Dermatitis herpetiformis (itchy skin rash)
- Mouth Ulcers
- Tingling or numbness in the hands and feet
- Bone or joint pain
Celiac Disease in Children
- Failure to thrive
- Delayed puberty
- Short stature
- Defects of permanent teeth
- Weight loss
- Pale, foul-smelling or fatty stool
- Abdominal pain and bloating
- Chronic diarrhea
Celiac disease has a genetic disposition and is most common in Caucasians of Northern European descent. First relatives of someone diagnosed with the disease have a 1 in 22 chance of having signs of the disease in their lifetime. Uncontrolled celiac disease predisposes patients to gut carcinomas and lymphomas.
Celiac disease tests are ordered when someone has signs and symptoms suggesting celiac disease, malnutrition, and/or malabsorption. The symptoms are often nonspecific and variable, making the disease difficult to spot. The symptoms may be mild for some time, going unnoticed, and then progressively worsen or occur sporadically.
- Vibrant™ Anti-tTg IgA
- Vibrant™ Anti-tTg IgG
- Vibrant™ Anti-dGP IgA
- Vibrant™ Anti-dGP IgG
- Total IgA
Other tests may be ordered to help determine the severity of the disease and the extent of the complications a person may experience, such as malnutrition, malabsorption, and the involvement of other organs. Tests may include:
- CBC (complete blood count) to look for anemia
- ESR (erythrocyte sedimentation rate) to evaluate inflammation
- hs-CRP (High Sensitivity C-Reactive protein) to evaluate inflammation
- CMP (comprehensive metabolic panel) to determine electrolyte, protein, and calcium levels, and to verify the status of the kidney and liver
- Vitamin D and B12 and folate to measure vitamin deficiencies
- Iron, iron binding capacity or transferrin, and ferritin to detect iron deficiency
If the test results indicate absence of antibodies tested for celiac disease, confirm your patient was eating a normal, gluten-containing diet for a least 3 weeks prior to testing. If not, the test results may have been compromised. If the patient was eating normally, there is a chance he/she has non-celiac gluten sensitivity.
Celiac Disease Test Interpretation
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4. Prince, H.E. (2006). Evaluation of the INOVA diagnostics enzyme-linked immunosorbent assay kits for measuring serum immunoglobulin G (IgG) and IgA to deamidated gliadin peptides. Clin Vaccine Immunol, 13, 594-151.
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