Women’s Health and Wellness

Taking control of your health starts with you!

Vibrant Cares About Women’s Health!

Vibrant America offers a complete hormone testing menu that is essential to evaluating and determining your overall health and well being.

When is it necessary to order?

When you suspect hormonal imbalance is affecting your sleep patterns, energy levels, and mood.

To assess reproductive, sexual health and age-related hormonal imbalances.

When evaluating polycystic ovary syndrome (PCOS) or suspicion of thyroid dysfunction.

Tests

Cortisol

This is the adrenal “stress hormone” that is elevated with both physical or emotional stressors and it plays a role in the metabolism of proteins, lipids, and carbohydrates.

Estradiol

To measure or monitor your estrogen levels; to detect an abnormal level or hormone imbalance; to monitor treatment for infertility or symptoms of menopause.

LH and FSH

Regulate and stimulate the growth and function of the ovaries and is used to evaluate fertility issues and function of other reproductive organs.

Progesterone

To help determine the cause of infertility, track ovulation, help diagnose an ectopic or failing pregnancy, monitor the health of a pregnancy, monitor progesterone replacement therapy, or help diagnose the cause of abnormal uterine bleeding.

Total Testosterone

In women is useful in the determination of risk for cardiovascular disease but the most frequent cause of elevated testosterone levels, is polycystic ovarian syndrome, however high levels are also associated with insulin resistance, abdominal obesity, abnormal lipids, and chronic inflammation.

SHBG

Produced by the liver, SHBG is a protein that is tightly bound to testosterone, estrogen and DHT. SHBG is a mechanism for transporting these hormones in inactive form. These levels can effect the amount of testosterone that is used by the body’s tissues.

Estrone

There are 3 major biologically active estrogens in humans: estrone (E1), estradiol (E2), and estriol (E3). Most of the circulating E1 is derived from peripheral aromatization of androstenedione (mainly adrenal). E2 and E1 can be converted into each other, and both can be inactivated via hydroxylation and conjugation. E2 demonstrates 1.25 – 5s times the biological potency of E1. E2 circulates at 1.5 – 4 times the concentration of E1 in premenopausal, nonpregnant women. E2 levels in men and postmenopausal women are much lower than in nonpregnant women, while E1 levels differ less, resulting in a reversal of the premenopausal E2:E1 ratio.

Estriol

There are 3 major biologically active estrogens in humans: estrone (E1), estradiol (E2), and estriol (E3). During pregnancy, E3 becomes the dominant estrogen. The fetal adrenal gland secretes dehydroepiandrosterone-sulfate (DHEAS), which is converted to E3 in the placenta and diffuses into the maternal circulation. The half-life of unconjugated E3 (uE3) in the maternal blood system is 20 to 30 minutes, since the maternal liver quickly conjugates E3 to make it more water soluble for urinary excretion. E3 levels increase throughout the course of pregnancy, peaking at term.

Prolactin

Prolactin is a hormone that is best known for its role in enabling milk production. It is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation and nursing. Prolactin plays an essential role in metabolism, regulation of the immune system and pancreatic development. The hormone counteracts the effect of dopamine. Elevated levels of prolactin decrease the levels of sex hormones — estrogen in women and testosterone in men. The effects of mildly elevated levels of prolactin are much more variable, in women, substantially increasing or decreasing estrogen levels.

Pregnenolone

Pregnenolone is the first steroid to be derived from cholesterol in the pathway of steroidogenesis, and it is the common precursor for all of the adrenal and gonadal steroids. Its production occurs in the mitochondrion by cleavage of the C-20 side chain of cholesterol by the P-450SCC enzyme. Once produced, pregnenolone may be utilized by two pathways of steroidogenesis. Pregnenolone may either be converted to 17-OH pregnenolone via the enzymatic action of 17α-hydroxylase or to progesterone via the enzymatic action of 3β- hydroxysteroid dehydrogenase.

Dihydrotestosterone (DHT)

DHT is an endogenous androgen sex steroid and hormone. DHT is biologically important for sexual differentiation of the male genitalia during embryogenesis, maturation of the penis and scrotum at puberty, growth of facial, body, and pubic hair, and development and maintenance of the prostate gland and seminal vesicles. It is produced from the less potent testosterone by the enzyme 5α-reductase in select tissues, and is the primary androgen in the genitals, prostate gland, seminal vesicles, skin, and hair follicles.

Anemia and Iron Deficiency
Diabetes, Weight Management, Thyroids

HOW DO YOU ORDER VIBRANT’S WOMEN’S HEALTH TEST?

Vibrant’s women’s health test is only available to order through your provider. If your physician is not in our network, please contact us.

Hormone Health

  • Hormones play an important role in women’s health.

  • Estrogen and progesterone are probably the most important hormones when evaluating reproductive health.

  • In addition to these sex hormones, your body also makes and uses other important hormones that can have an effect on your overall health, such as your energy level, weight, mood, and sleep patterns.

This test has been developed and its performance characteristics determined by the CLIA-certified laboratory performing the test. This test has not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests.

1. Bidlingmaier F, Wagner-Barnack M, Butenandt O, Knorr D: Plasma estrogens in childhood and puberty under physiologic and pathologic conditions. Pediatr Res 1973;7(11):901-907

2. Elmlinger MW, Kuhnel W, Ranke MB: Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adults. Clin Chem Lab Med 2002;40(11):1151-1160

3. Cummings SR, Browner WS, Bauer D, et al: Endogenous hormones and the risk of hip and vertebral frac-tures among older women. N Engl J Med 1998;339:733-738

4. Iughetti L, Predieri B, Ferrari M, et al: Diagnosis of central precocious puberty: endocrine assessment. J Pediatr Endocrinol Metab 2000;13 Suppl 1:709-715

5. Ismail AA, Barth JH: Endocrinology of gynaecomastia. Ann Clin Biochem 2001;38:596-607

6. Kligman I, Rosenwaks Z: Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders. Fertil Steril 2001;76:1185-1190

7. Traggiai C, Stanhope R: Delayed puberty. Best Pract Res Clin Endocrinol Metab 2002;16:139-151